Publications by authors named "Tina Daigneault"
Local intragraft humoral immune responses in chronic lung allograft dysfunction.
J Heart Lung Transplant
January 2025
Article Synopsis
- The study investigates the production of donor-specific antibodies (DSA) and non-HLA antibodies in lungs affected by chronic lung allograft dysfunction (CLAD) after transplantation.
- Researchers cultured lung tissue samples from 15 CLAD patients, discovering that DSA and non-HLA antibodies were produced locally in the lungs and correlated with activated B cells.
- The findings suggest that activated B cells in CLAD lungs may contribute to the development of these antibodies, indicating a local immune response rather than relying solely on circulation.
Chronic lung allograft dysfunction (CLAD) is a major complication after lung transplantation that results from a complex interplay of innate inflammatory and alloimmune factors, culminating in parenchymal and/or obliterative airway fibrosis. Excessive IL-17A signaling and chronic inflammation have been recognized as key factors in these pathological processes. Herein, we developed a model of repeated airway inflammation in mouse minor alloantigen-mismatched single-lung transplantation.
View Article and Find Full Text PDFBackground: T helper 17 (Th17) cells produce IL-17A cytokine and can exacerbate autoimmune diseases and asthma. The β2 adrenergic receptor is a g protein-coupled receptor that induces cAMP second messenger pathways. We tested the hypothesis that terbutaline, a β2-adrenergic receptor-specific agonist, promotes IL-17 secretion by memory Th17 cells in a cAMP and PKA-dependent manner.
View Article and Find Full Text PDFChronic lung allograft dysfunction (CLAD) is the major cause of death after lung transplantation. Angiotensin II (AngII), the main effector of the renin-angiotensin system, elicits fibrosis in both kidney and lung. We identified six AngII-regulated proteins (Ras homolog family member B (RHOB), bone marrow stromal cell antigen 1 (BST1), lysophospholipase 1 (LYPA1), glutamine synthetase (GLNA), thrombospondin 1 (TSP1) and laminin subunit β2 (LAMB2)) that were increased in urine of patients with kidney allograft fibrosis.
View Article and Find Full Text PDFVasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response.
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