Publications by authors named "Timur Yildirim"

Background: Homogeneous intraocular lens (IOL) calcification deteriorates patient's visual quality. There is a lack of functional and patient-reported data on patients with this material change undergoing IOL exchange surgery. The aim of this study was to evaluate subjective and objective outcomes following IOL exchange due to homogeneous IOL calcification to improve evidence-based patient counseling.

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Purpose: To assess visual outcomes and stability of lens alignment more than 3 years after implanting either the AT Lisa Tri Toric (Carl Zeiss Meditec) or the Acrysof IQ Restor Toric (Alcon Laboratories, Inc) intraocular lens (IOL).

Methods: Patients who had received either the AT Lisa Tri Toric or the Acrysof IQ Restor Toric IOL were included in the study. The average follow-up period was 5.

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Article Synopsis
  • The study aimed to explore how calcium and phosphorus levels influence optical deterioration in intraocular lenses (IOLs) that have calcified.
  • Researchers analyzed 18 explanted IOLs, identifying differences between primary and secondary calcification by measuring straylight and light loss.
  • Findings revealed primary calcified IOLs had significantly higher calcium and phosphorus content, leading to greater optical impairment compared to secondary calcification, highlighting the importance of these minerals in visual quality deterioration.
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Article Synopsis
  • The study investigates the relationship between phosphate levels in aqueous humor and the risk of calcification in intraocular lenses (IOLs), especially in diabetic patients.
  • In vitro tests involved different IOL models exposed to varying phosphate concentrations to assess calcification using several analytical methods.
  • Results indicated that higher phosphate concentrations and longer exposure times significantly increased the risk of IOL calcification, supporting the hypothesis that diabetic conditions may elevate this risk.
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Purpose: In Descemet Membrane Endothelial Keratoplasty (DMEK) a gas bubble is usually used to attach the graft to the host cornea. In this study, we observed the bubble size and bubble-graft coverage at different gaze angles following DMEK.

Methods: This observational prospective study analyzed 465 images of patients who underwent an uneventful DMEK.

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Article Synopsis
  • The study analyzed data from over 2500 intraocular lens (IOL) explantations to determine the causes and characteristics of explantation within the first year after implantation.
  • The study found that 1.9% of IOLs were explanted early, mainly due to dislocation, visual intolerance, opacification, and intraoperative complications, with the fastest explantations occurring due to intraoperative issues.
  • The findings suggest that there are areas for improvement in IOL design and implantation techniques, especially concerning intraoperative damages and early calcification of hydrophilic IOLs.
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Background: In recent years intraocular lenses (IOLs) for correcting presbyopia have been significantly improved and diversified. There are currently many different IOL models based on a wide variety of optical designs.

Objective: The wide variety of available IOL solutions to correct presbyopia can be challenging for surgeons and patients.

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Mucopolysaccharidosis type 10 is caused by biallelic variants in ARSK, which encodes for a lysosomal sulfatase. To date, seven patients with a mild phenotype resembling spondyloepiphyseal dysplasia or multiple epiphyseal dysplasia have been described. In this report, we present two novel ARSK variants and report clinical and radiological findings of three patients.

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Introduction: The aim of this study was to analyze posterior surface opacification in explanted silicone intraocular lenses (IOLs) with clinicopathologic correlation to asteroid hyalosis.

Methods: In a laboratory setup, 12 explanted silicone IOLs underwent laboratory analyses, including light microscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy for elemental composition (EDX). Relevant clinical data were obtained for each case, including gender, age at IOL implantation, dates of implantation and explantation, as well as history of neodymium-dopped yttrium aluminum garnet (Nd:YAG) laser treatments or other opacification removal attempts.

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Cataract is among the leading causes of visual impairment worldwide. Innovations in treatment have drastically improved patient outcomes, but to be properly implemented, it is necessary to have the right diagnostic tools. This review explores the cataract grading systems developed by researchers in recent decades and provides insight into both merits and limitations.

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Objective: This study aimed to evaluate the diagnosis and treatment preferences of orthopedic surgeons in developmental dysplasia of the hip (DDH) cases under the age of 1 in Türkiye with a higher incidence of DDH, estimated to be around 5-15 per 1000 live births.

Methods: This was a nationwide cross-sectional survey. A link for the online survey, including 16 multiple-choice questions, was sent to the email group of the National Orthopedic Society.

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Background: Chromatic aberration of the eye results from the dispersion of polychromatic light at the interfaces of ocular media. An intraocular lens (IOL) based approach utilizing the diffractive-multifocal principle has been proposed for its correction, but the clinical evidence on the impact of reducing or increasing chromatic aberration on the visual quality of pseudophakic patients remains scarce.

Methods: In this cross-sectional study, longitudinal chromatic aberration (LCA) effects were studied monocularly in 37 patients implanted with a monofocal lens.

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Purpose: In intraocular lens (IOL) implantation, insertion of the IOL injector enlarges the clear corneal incision. A larger incision size (IS) is associated with a higher risk for surgically induced astigmatism and endophthalmitis. The goal of this study was to determine which parameters most influence the final IS.

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Purpose: We evaluated implantation behavior and injector damage of two different IOL injector systems, the Multisert and the AutonoMe.

Design: Prospective, randomized, comparative study with laboratory investigation.

Methods: We examined used injectors from 48 bilateral cataract cases and assessed video recordings of each Implantation.

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Differentiating between various intraocular lens (IOL) changes can be a challenge. In particular, certain IOL models carry the risk of late postoperative calcification. A major cause of IOL exchange surgery could be avoided if appropriate modifications were made during the IOL manufacturing process.

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Background: Keratoconus is a bilateral, yet asymmetric disease. In rare cases, the second eye may show no signs of tomographic changes. The purpose of this study was to analyze the biomechanical characteristics in tomographically regular keratoconus fellow eyes.

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Simultaneous implantation of a monofocal or monofocal toric intraocular lens (IOL) into the capsular bag and a multifocal IOL into the ciliary sulcus, referred to as duet procedure, allows us to create multifocality that is more easily reversible than the implantation of a capsular bag-fixated multifocal IOL. The optical quality and results after the duet procedure are equivalent to those of a capsular bag-fixated multifocal IOL. Patients who cannot tolerate the side effects of multifocal optics or who develop an ocular condition leading to loss of function such as age-related macular degeneration (AMD) or glaucoma in the course of their lives may benefit from the reversibility of the procedure.

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Purpose: The smaller incision, new-generation implantable miniature telescope is a novel implant to optimize vision in retinal patients with central vision loss. Using Miyake-Apple techniques we visualized the device implantation, repositioning, and explantation, while noting capsular bag dynamics.

Methods: Using the Miyake-Apple technique, we assessed capsular bag deformation after successful implantation of the device in human autopsy eyes.

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Aim: To determine the clinical risk factors that may increase the occurrence of intraocular lens (IOL) calcification in patients who had undergone pars plana vitrectomy (PPV).

Methods: The medical records of 14 patients who underwent IOL explantation due to clinically significant IOL opacification after PPV were reviewed. The date of primary cataract surgery, technique and implanted IOL characteristics; the time, cause and technique of PPV; tamponade used; additional surgeries; the time of IOL calcification and explantation; and IOL explantation technique were investigated.

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Article Synopsis
  • Opacification from calcification in hydrophilic acrylic intraocular lenses is a significant complication after cataract surgery, leading to the need to remove the lens.* -
  • The study aimed to assess whether hydrophobic surface properties of some hydrophilic acrylic lenses could reduce the risk of calcification compared to standard hydrophilic and hydrophobic lenses.* -
  • Results showed that all hydrophilic lenses, regardless of their surface properties, experienced calcification, while the hydrophobic lenses did not, indicating that hydrophobic surfaces do not prevent crystal formation.*
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In this meta-analysis and systematic literature review of refractive outcomes after Descemet membrane endothelial keratoplasty (DMEK), the extent of the refractive shift and an overview of reasons for refractive shift after DMEK are provided. The PubMed library was screened for articles containing the terms "Descemet membrane endothelial keratoplasty," "DMEK," "Descemet membrane endothelial keratoplasty combined with cataract surgery," "triple-DMEK" combined with "refractive outcomes," "refractive shift," and "hyperopic shift." The refractive outcomes after DMEK were analyzed and compared using a fixed and random effects model.

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To evaluate the long-term posterior capsule opacification (PCO) formation, and glistening rate of the HOYA Vivinex (XY1) IOL compared to Alcon AcrySof (SN60WF). In this prospective, multicentric, randomized, paired-eye, open-label study, we included 87 subjects that underwent cataract surgery with IOL implantation, with 67 patients completing the 3-year follow-up. The completer population consisted of 32 subjects implanted with XY1 and 35 implanted with SN60WF.

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Background: Although flexible flatfoot (FF) in children is a foot deformity that is frequently encountered in daily orthopedics practice, its etiology is still controversial. The aim of this study was to determine whether there is a weakness in muscle strength and proprioception in patients with FF.

Methods: The study group consisted of 16 cases with FF, and the control group consisted of 25 volunteers with normal feet.

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