Publications by authors named "Timur Prozorovski"
Article Synopsis
- Demyelinated brain lesions are caused by autoimmune diseases like multiple sclerosis and are linked to damage of oligodendroglial cells, mainly due to activated microglia producing nitric oxide, which causes myelin damage.
- Glutaredoxin 2 has been found to inhibit the formation of harmful peroxynitrite by converting nitric oxide into a less harmful compound and plays a crucial role in protecting oligodendrocyte cells and preserving myelin structure.
- The protective mechanism of glutaredoxin 2 is not related to its usual enzymatic function but rather involves the reconfiguration of its iron-sulfur cluster; thus, enhancing glutathione levels could be a potential therapeutic strategy for treating inflammatory demyelination.
