Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection.

Raman spectroscopy is a powerful analytical technique widely used for quantitative and qualitative analysis. However, the development of inexpensive, reproducible, and reusable enhancing substrates remains a challenge for material scientists and analytical chemists. In this study, we address this challenge by demonstrating the deposition of core-shell nanoparticles consisting of a gold core and a thin inert SiO shell within a confined space, resulting in the formation of a highly efficient Raman-enhancing structure.