Prevalence of hepatitis B e antigen in chronic HBV carriers in North-central Nigeria.

Hepatitis B virus (HBV) is an important clinical problem due to its worldwide distribution and potential of adverse sequelae, including hepatocellular carcinoma (HCC). We studied the prevalence of hepatitis B virus e antigen (HBeAg) among individuals determined to be HBV surface antigen-positive (HBsAg+) and analyzed the gender/age category associated with more active HBV infection. A total of 572 HBsAg+ individuals, as determined by a double antibody sandwich ELISA method, participated in the study.

Hepatitis B virus infections in apparently healthy urban Nigerians: data from pre-vaccination tests.

Background: In spite of the availability of an effective vaccine since 1982 against hepatitis B, infection with hepatitis B virus (HBV), which is 50 to 100 times more infectious than HIV, still persists in most parts of the world with Nigeria being described as an endemic zone. We therefore set out to establish the prevalence of this infection and evaluate its relationship with age and gender in urban Nigerians.

Methodology: During pre-vaccination tests, blood samples were collected by finger-prick and venepuncture from 1,891 subjects aged < or = 60 years, between 2008 and 2009 after having obtained informed consent and ethical clearance.