Publications by authors named "Timothy S Fitzsimmons"
Front Med (Lausanne)
May 2023
Article Synopsis
- Immune checkpoint inhibitors (ICPI) are a cancer treatment that can be used for various tumor types, but their trials have mostly focused on specific cancer sites. This study reviews trial data to evaluate the effectiveness of these treatments based on PD-L1 expression as a potential biomarker for broader cancer applications.
- A systematic literature review was conducted on multiple databases, targeting studies involving adults with solid cancers (excluding melanomas) treated with ICPIs, emphasizing phase III randomized control trials for measuring outcomes like overall survival and adverse effects.
- The meta-analysis included 46,510 participants and found that ICPIs significantly improved overall survival, particularly in lung cancers, head and neck cancers, and gastroesophageal junction cancers, with overall survival rates differing in
