Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review.

Purpose: To evaluate the effectiveness and tolerability of zonisamide in children with epilepsy.

Method: Retrospective case note review of young people (less than 19 years) with epilepsy from three UK tertiary centres who received treatment with zonisamide and were followed up for a minimum of 12 months.

Results: Fifty-seven children were included, aged 1.

Epilepsy with reversible bulbar dysfunction.

In patients with focal epilepsy, focal neurological dysfunction can occur due to status epilepticus and also as a post-ictal phenomenon. Bulbar dysfunction as evident by drooling, dysarthria, swallowing difficulties, and palatal-glossalpharyngeal weakness has been reported in conjunction with epilepsy. This is non-progressive and is correlated in its severity with the frequency of seizures.