COVID-19-associated acute disseminated encephalomyelitis (ADEM).

A 51-year-old woman with COVID-19 infection developed coma and an impaired oculocephalic response to one side. MRI of the brain demonstrated acute multifocal demyelinating lesions, and CSF testing did not identify a direct cerebral infection. High-dose steroids followed by a course of IVIG was administered, and the patient regained consciousness over the course of several weeks.

Tumefactive multiple sclerosis: a case report and review of the literature.

Tumefactive multiple sclerosis (TMS) is a rare subset of inflammatory demyelinating disorders that can present with MS symptoms or the clinical or radiographic findings of a space-occupying intracranial lesion. Classically, TMS presents on computed tomography (CT) or magnetic resonance imaging (MRI) with an intracranial mass greater than 2.0 cm with a variable amount of mass effect, edema, and ring or rim enhancement with gadolinium contrast.

Intense pain soon after wrist fracture strongly predicts who will develop complex regional pain syndrome: prospective cohort study.

Unlabelled: Complex regional pain syndrome (CRPS) is a distressing and difficult-to-treat complication of wrist fracture. Estimates of the incidence of CRPS after wrist fracture vary greatly. It is not currently possible to identify who will go on to develop CRPS after wrist fracture.

Autonomic symptoms in carriers of the m.3243A>G mitochondrial DNA mutation.

Background: The m.3243A>G mutation can cause multisystem medical problems and can affect the autonomic nervous system.

Objective: To study the frequency and spectrum of autonomic symptoms associated with the m.

A novel tRNA(Val) mitochondrial DNA mutation causing MELAS.

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is the most common mitochondrial disease due to mitochondrial DNA (mtDNA) mutations. At least 15 distinct mtDNA mutations have been associated with MELAS, and about 80% of the cases are caused by the A3243G tRNA(Leu(UUR)) gene mutation. We report here a novel tRNA(Val) mutation in a 37-year-old woman with manifestations of MELAS, and compare her clinicopathological phenotype with other rare cases associated tRNA(Val) mutations.