Kölliker's Organ Functions as a Developmental Hub in Mouse Cochlea regulating spiral limbus and tectorial membrane development.

Kölliker's organ is a transient developmental structure in the mouse cochlea that undergoes significant remodeling postnatally. Utilizing an epithelial-specific conditional deletion mouse model of (marker and regulator of Kölliker's organ), we show that is required for interdental cell development, and thereby the development of the limbal domain of the tectorial membrane and its medial anchorage to the spiral limbus. Additionally, we show that Kölliker's organ is involved in normal tectorial membrane collagen fibril development and maturation.