Publications by authors named "Timothy Mutuma"
Background: The emergence and spread of β-lactamase-producing Klebsiella spp. has been associated with a substantial healthcare burden resulting in therapeutic failures. We sought to describe the proportion of phenotypic resistance to commonly used antibiotics, characterize β-lactamase genes among isolates with antimicrobial resistance (AMR), and assess the correlates of phenotypic AMR in Klebsiella spp.
View Article and Find Full Text PDFPlasmid-mediated quinolone resistance genes detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya.
Kevin Kariuki Mame Mareme Diakhate Susan Musembi Stephanie N Tornberg-Belanger Doreen Rwigi Timothy Mutuma
BMC Microbiol
May 2023
Article Synopsis
- The study found a high prevalence of ciprofloxacin non-susceptible E. coli and Klebsiella spp in children under five after hospital discharge, with around 68% of the isolates exhibiting resistance.
- About 80% of resistant isolates carried plasmid-mediated quinolone resistance genes, with aac(6')lb-cr being the most common.
- Factors such as ceftriaxone use during hospitalization and ESBL production were significantly linked to the presence of these resistant bacteria.