Publications by authors named "Timothy McGaw"
Introduction: Sjögren's syndrome (SS) presents complex diagnostic challenges due to its multi-organ involvement, often leading to misdiagnosis, which can result in unnecessary treatments, elevated healthcare costs, and significant impacts on patient quality of life. Accurate diagnosis is therefore critical, utilising ACR/EULAR criteria that include both labial minor salivary gland (LMSG) biopsy and anti-SSA antibodies.
Methods: This retrospective study analysed medical records of 87 adults suspected of primary SS, who underwent both anti-SSA serology and LMSG biopsy.
Article Synopsis
- - The review aimed to determine if existing studies on diagnostic accuracy support the current ACR/EULAR guidelines for diagnosing Sjögren's syndrome (SS), focusing on literature from databases like Medline and Embase.
- - Despite examining three studies, the review found their designs were inadequate, leading to a lack of conclusive findings about the effectiveness of the diagnostic tests for SS, preventing a meta-analysis due to significant differences in methodologies.
- - The authors concluded that better-designed studies are necessary to either verify the current diagnostic guidelines for SS or propose modifications, as the existing studies did not allow for strong recommendations.
Long-term outcomes of submandibular gland transfer for prevention of postradiation xerostomia.
Arch Otolaryngol Head Neck Surg
August 2004
Background: Xerostomia is a permanent and devastating sequela of head and neck irradiation, and its numerous consequences affect most aspects of the patient's life. A new method of preserving and protecting a single submandibular gland from radiation damage through the Seikaly-Jha procedure (SJP) has recently been described.
Objective: To report the long-term outcomes of the SJP.
Background And Purpose: Xerostomia is a significant morbidity of radiation treatment in the management of head and neck cancers. We hypothesized that the surgical transfer of one submandibular salivary gland to the submental space, where it can be shielded from radiation treatment (XRT), would prevent xerostomia.
Materials And Methods: We conducted a prospective Phase II clinical trial and the patients were followed clinically with salivary flow studies and the University of Washington Quality of Life questionnaire.