Publications by authors named "Timothy Liang"

Article Synopsis
  • The study focused on understanding SCN5A-related cardiomyopathies by creating ventricular cardiomyocytes from stem cells of a dilated cardiomyopathy patient with the R222Q mutation.
  • Using heart-on-a-chip biowires, researchers found that the R222Q mutation led to arrhythmias, altered sodium channel properties, and decreased heart muscle contractility compared to controls.
  • RNA sequencing revealed significant differences in gene regulation affecting calcium handling and sarcomere structure, highlighting the mutation's impact on both cardiac electrical activity and mechanical stability.
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Background: In agreement with Association of American Medical Colleges guidelines, the 2020 to 2021 integrated vascular surgery (I-VS) residency interviews were conducted virtually. In the present study, we collected data about the virtual interview process from the applicant's perspective, including preferences for interview format and the virtual resources they found most helpful.

Methods: An anonymous, online survey study of medical students who had been accepted into I-VS residencies during the 2020 to 2021 application cycle was performed.

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Objective: Hip fractures are associated with significant morbidity and mortality. Ultrasound-guided peripheral nerve blocks are a safe method to manage pain and decrease opioid usage. The pericapsular nerve group (PENG) block is a novel, potentially superior block because of its motor-sparing effects.

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Background: We developed a multi-axes lead (Max) incorporating 4 electrodes arranged at the lead-tip, organized in an equidistant tetrahedron. Here, we studied Max performance in sensing, pacing, and activation wavefront-direction analysis.

Methods: Sixteen explanted animal hearts (from 7 pigs, 7 sheep, and 2 rabbits) were used.

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Background: The American College of Surgeons Bleeding Control Course (B-Con) empowers bystanders with hemorrhage control skills to manage prehospital emergencies, but demonstrates poor skill retention. The point of care use of a free Stop the Bleed mobile phone application on the retention of hemorrhage control skills from the B-Con Course was explored.

Methods: Convenience sample of college students previously trained in B-Con were randomized into mobile application (MA) or control groups.

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Background: The safety and efficacy parameters for bipolar radiofrequency (RF) ablation are not well defined.

Objective: The purpose of this study was to investigate the safe range of power, utility of transmyocardial bipolar electrogram (EGM) amplitude, and circuit impedance in ablation monitoring.

Methods: Sixteen beating ex vivo human and swine hearts were studied in a Langendorff setup.

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Cardiac arrhythmias impact over 12 million people globally, with an increasing incidence of acquired arrhythmias. Although animal models have shed light onto fundamental arrhythmic mechanisms, species-specific differences and ethical concerns remain. Current human models using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) either lack the higher order tissue organization of the heart or implement unreliable arrhythmia induction techniques.

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Objective: A precursor to more severe forms of Myasthenia Gravis (MG) is ocular MG (OMG) in which the MG symptoms are localized to the eyes. Current MG diagnostic methods are often invasive, painful, and not always specific. The objective of the proposed work was to extract quantifiable features from electrooculography (EOG) signals recorded around the eyes and develop an alternative non-invasive screening method for detecting MG.

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Background: Noninvasive electrocardiographic mapping of ventricular tachycardia (VT) and ablation using stereotactic radiotherapy was recently reported. This strategy does not directly evaluate the critical diastolic components and assumes that the epicardial exit site of VT subtends closely over the endocardial mid-diastolic isthmus.

Objective: To determine if the epicardial exit site of VT spatially corresponds to the critical diastolic components of ischemic scar-related VT.

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There is no known strategy to differentiate which multicomponent electrograms in sinus rhythm maintain reentrant ventricular tachycardia (VT). Low entropy in the voltage breakdown of a multicomponent electrogram can localize conditions suitable for reentry but has not been validated against the classic VT activation mapping. We examined whether low entropy in a late and diversely activated ventricular scar region characterizes and differentiates the diastolic path of VT and represents protected tissue channels devoid of side branches.

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