Publications by authors named "Timothy Kit Hin Lee"
Targeted antineoplastic immunotherapies have achieved remarkable clinical outcomes. However, resistance to these therapies due to target absence or antigen shedding limits their efficacy and excludes tumours from candidacy. To address this limitation, here we engineer an oncolytic rhabdovirus, vesicular stomatitis virus (VSVΔ51), to express a truncated targeted antigen, which allows for HER2-targeting with trastuzumab.
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- The HIV envelope glycoprotein (Env) is crucial for viral binding and immune responses but is difficult to target due to its complex structure and variability.
- Flow virometry (FV) allows researchers to study HIV virions at the single-particle level using a range of monoclonal antibodies, demonstrating its effectiveness in characterizing Env.
- The study highlights that both the production method of the virus and the addition of soluble CD4 can significantly influence the detection and conformation of Env on HIV virions.