Publications by authors named "Timothy K O'Malley"
Objective: Fatty liver disease is increased among individuals with HIV. We sought to explore how aldosterone, a key hormone linked to insulin resistance and inflammation, relates to liver fat in the large population of individuals with HIV and metabolic abnormalities.
Methods: Forty-six individuals with HIV and increased waist circumference and dysglycemia were assessed for liver fat using proton magnetic resonance spectroscopy.
Article Synopsis
- HIV-infected individuals may have issues like insulin resistance and inflammation, leading researchers to explore eplerenone, a mineralocorticoid receptor blocker, to improve their metabolic health.* -
- A six-month trial was conducted with 46 participants who received either eplerenone or a placebo, focusing on insulin sensitivity and metabolic parameters.* -
- While eplerenone didn't significantly enhance insulin sensitivity, it did lead to some improvements in fat and inflammatory markers and was well tolerated without major side effects.*
Background: Mechanisms underlying the heightened myocardial infarction risk among HIV-infected women (versus non-HIV-infected women) remain unclear. Our objectives were to assess epicardial adipose tissue (EAT) volume and its associations among asymptomatic women with and without HIV.
Methods: A total of 55 HIV-infected and 27 non-HIV-infected women without known cardiovascular disease who underwent cardiac CT and metabolic/immune phenotyping were included.
: The well treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating soluble CD163, soluble CD14, and monocyte chemoattract protein 1.
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