Publications by authors named "Timothy Jc Anderson"
Article Synopsis
- - The study explores the microbiome of spp. snails, which play a role in transmitting human pathogens, revealing a diverse and distinct microbiome present in the snails' hemolymph compared to their water environment.
- - Researchers dissected two different snail species and sampled their organs, demonstrating that each organ has its own specific microbiome with lower diversity compared to the overall hemolymph and whole-snail microbiomes.
- - The findings highlight the importance of analyzing individual organ microbiomes to fully understand the overall snail microbiome and its implications for health and disease research.
The emergence of mutant K13-mediated artemisinin (ART) resistance in malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing dominance of wild-type K13 elsewhere. Using gene editing, we show that R561H, along with C580Y and M579I, confer elevated in vitro ART resistance in some African strains, contrasting with minimal changes in ART susceptibility in others.
View Article and Find Full Text PDFRational approach to drug discovery for human schistosomiasis.
Int J Parasitol Drugs Drug Resist
August 2021
Human schistosomiasis is a debilitating, life-threatening disease affecting more than 229 million people in as many as 78 countries. There is only one drug of choice effective against all three major species of Schistosoma, praziquantel (PZQ). However, as with many monotherapies, evidence for resistance is emerging in the field and can be selected for in the laboratory.
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