Publications by authors named "Timothy J Leaver"
Article Synopsis
- Nanomedicines help improve treatments for diseases but are hard and expensive to produce with old methods.
- This study looks at a new way to make nanomedicines using special devices called microfluidic cartridges that can produce large amounts quickly and consistently.
- By testing different designs, researchers found a way to make liposomes (tiny drug carriers) faster and with better quality, making it easier to create products for patients effectively.
Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions containing siRNA. Current formulation procedures employ macroscopic mixing processes to produce systems 70-nm diameter or larger that have variable siRNA encapsulation efficiency, homogeneity, and reproducibility.
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