Publications by authors named "Timothy J Craine"
Article Synopsis
- Impaired attention is a key cognitive issue for TBI survivors, impacting their recovery and daily life.
- A study tested rats with moderate TBI using a task designed to mimic human attention tests, showing that both male and female rats had decreased accuracy and increased errors post-injury.
- Results indicate that these attention deficits are significant and lasting, especially when cues are presented on one side, which relates to a common clinical condition called hemispatial neglect.
Traumatic brain injuries (TBIs) affect more than 10 million patients annually worldwide, causing long-term cognitive and psychosocial impairments. Frontal lobe TBIs commonly impair executive function, but laboratory models typically focus primarily on spatial learning and declarative memory. We implemented a multi-modal approach for clinically relevant cognitive-behavioral assessments of frontal lobe function in rats with TBI and assessed treatment benefits of the serotonin-norepinephrine reuptake inhibitor, milnacipran (MLN).
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