Publications by authors named "Timothy Grover"
Article Synopsis
- Patients with Parkinson's disease often struggle with axial symptoms like speech and balance issues, and while high-frequency deep brain stimulation can worsen these symptoms, low-frequency stimulation may help, but its effectiveness varies among individuals.
- This study aims to verify the benefits of low-frequency stimulation on axial symptoms and identify factors that may predict its long-term effectiveness, focusing on a group of patients who struggled with high-frequency stimulation.
- Results from 20 patients showed short-term improvements in motor function and quality of life with low-frequency stimulation, while a larger retrospective analysis identified characteristics like less severe tremor as predictors for sustained long-term use of this treatment.
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is a widely used treatment for Parkinson's disease (PD) patients with motor complications, but can result in adverse effects (AEs) in a significant proportion of treated patients. The use of novel programming features including short pulse width (PW) and directional steering in alleviating stimulation-induced AEs has not been explored.
Objective: To determine if programming with short PW, directional steering, or the combination of these novel techniques can improve stimulation-induced dysarthria, dyskinesia, and pyramidal AEs.
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for selected Parkinson's disease patients with motor fluctuations, but can adversely affect speech and axial symptoms. The use of short pulse width (PW) has been shown to expand the therapeutic window acutely, but its utility in reducing side effects in chronic STN-DBS patients has not been evaluated.
Objective: To compare the effect of short PW settings using 30-μs with conventional 60-μs settings on stimulation-induced dysarthria in Parkinson's disease patients with previously implanted STN-DBS systems.
Background: Subthalamic deep brain stimulation (STN-DBS) is an established treatment for late stage Parkinson's disease (PD). Speech intelligibility (SI) and verbal fluency (VF) have been shown to deteriorate following chronic STN-DBS. It has been suggested that speech might respond favourably to low frequency stimulation (LFS).
View Article and Find Full Text PDFBackground: Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for selected Parkinson's disease (PD) patients, but therapy is often limited by side effects. Previous studies indicate an inverse relationship of the therapeutic window (TW) to pulse width (PW) settings down to 60μs, but there is limited data available on the effect of shorter PWs.
Objective: To define the TW of STN-DBS in PD at PW of 30μs (PW30) relative to standard PW settings at 60μs (PW60), and to compare speed of gait and speech intelligibility on the two PW conditions.