Risperidone long-acting injection and Huntington's disease: case series with significant psychiatric and behavioural symptoms.

There is currently no known disease-altering treatment for Huntington's disease (HD). Successful symptomatic treatment often involves antipsychotic medication, including risperidone, yet the evidence base is limited to case reports. Although noncompliance to oral antipsychotic drugs can be a practical problem, especially when significant psychiatric manifestations of HD are present, the effect of depot antipsychotic medication in HD remains largely unknown.

The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland.

Low plasma folate and its derivatives have been linked with depressive disorders in studies dating back over 30 years. A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate. The present study aimed to explore whether the thermolabile variant of MTHFR is associated with a vulnerability to depressive episodes.

The Derryhirk Inn incident: the psychological sequelae.

A major incident occurred in a Northern Ireland bar in March 1997. One hundred and fifty customers were held at gunpoint. No one sustained any serious physical injury.