Publications by authors named "Timothy F Drevyanko"
Article Synopsis
- The study aimed to evaluate the effectiveness of induction chemotherapy before trimodality therapy in patients with esophageal or gastroesophageal junction adenocarcinoma, building on previous findings that suggested potential survival benefits.
- In a phase 2 trial involving 28 centers, patients were randomly assigned to receive either induction chemotherapy (Arm A) or none (Arm B) followed by standard treatment, with pathologic complete response (pathCR) as the primary measure of success.
- Results indicated that while the primary endpoint (pathCR) was not improved, patients receiving induction chemotherapy had significantly longer overall survival and disease-free survival, especially those with well/moderately differentiated tumors, prompting further investigation in future trials.
