Long-Term Effects of a Photodisruptive Laser-Induced Traumatic Neuropathy Model.

Purpose: To create a mouse traumatic optic neuropathy (TON) model that is reproducible, reliable, and easy to manipulate with high specificity to retinal ganglion cell (RGC) layer and no mortality. The model will be useful for understanding the pathophysiology of retinal ganglion cell death and for testing neuroprotective therapeutics.

Methods: An Nd:YAG laser was used to generate focal photodisruptive retinal damage.