Publications by authors named "Timothy Csernica"
Article Synopsis
- Stable isotopes can be used in forensic investigations to identify the source and degradation mechanisms of compounds, acting like a chemical fingerprint.
- Traditional methods for analyzing specific precursors of sarin required different techniques and sample preparations, making them less efficient.
- The new Orbitrap isotope ratio mass spectrometry (Orbitrap-IRMS) technique allows simultaneous measurement of carbon and hydrogen in methylphosphonic acid (MPA), providing a faster and more precise forensic analysis than previous methods.
Background: We have developed a new clinical research approach for the quantification of cellular proliferation in human infants to address unanswered questions about tissue renewal and regeneration. The approach consists of oral 15N-thymidine administration to label cells in S-phase, followed by Multi-isotope Imaging Mass Spectrometry for detection of the incorporated label in cell nuclei. To establish the approach, we performed an observational study to examine uptake and elimination of 15N-thymidine.
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