Publications by authors named "Timothy Cha"

Regulation of food intake and energy balance is critical to survival. Hunger develops as a response to energy deficit and drives food-seeking and consumption. However, motivations to eat are varied in nature, and promoted by factors other than energy deficit.

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Regulation of food intake and energy balance is critical to survival. Hunger develops as a response to energy deficit and drives food-seeking and consumption. However, motivations to eat are varied in nature, and promoted by factors other than energy deficit.

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Article Synopsis
  • Current treatments for craniofacial bone abnormalities, which include surgeries and bone grafts, are costly and have significant limitations, with some therapies posing serious health risks.
  • Bone morphogenetic protein 2 (BMP2) has issues like overgrowth and inflammation, while stem cell therapies are promising but not FDA approved and resource-heavy.
  • Research suggests that JAGGED1 can effectively promote bone regeneration in pediatric patients by inducing specific signaling pathways in osteoblasts, presenting a potential innovative treatment option for craniofacial bone loss.
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Treatments for congenital and acquired craniofacial (CF) bone abnormalities are limited and expensive. Current reconstructive methods include surgical correction of injuries, short-term bone stabilization, and long-term use of bone grafting solutions, including implantation of (i) allografts which are prone to implant failure or infection, (ii) autografts which are limited in supply. Current bone regenerative approaches have consistently relied on BMP2 application with or without addition of stem cells.

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Article Synopsis
  • A novel biosensor utilizing guanine-rich DNA aptamer-conjugated 6-carboxyfluorescein (6-FAM) was developed to detect prostate-specific antigen (PSA) in human serum quickly and cost-effectively for early prostate cancer diagnosis.
  • The sensor functions based on chemiluminescent resonance energy transfer (CRET), where the presence of PSA inhibits light emission by interfering with the reaction between 6-FAM and guanine.
  • This chemiluminescent biosensor can accurately measure PSA levels in just 30 minutes, with a detection limit of 1.0 ng/ml, demonstrating high accuracy compared to traditional methods, and may serve as a new tool for prostate cancer
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