Publications by authors named "Timothy A Lyerla"

Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous inherited disease causing hypopigmentation and prolonged bleeding times. An additional serious clinical problem of HPS is the development of lung pathology, which may lead to severe lung disease and premature death. No cure for the disease exists, and previously, no animal model for the HPS lung abnormalities has been reported.

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Some chemical properties of the orange pigment from eggs and embryos and the mantle tissue of adult Ecteinascidia turbinata, as well as ultrastructural characteristics of pigment masses in the mantle, have been examined. The diffuse egg and embryo pigment has solubility and absorbence characteristics of carotenoids, which are solubilized within yolk platelets. The granular mantle pigment, however, is not carotenoid.

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