Molecular detection of Gram-positive bacteria in the human lung through an optical fiber-based endoscope.

Purpose: The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we developed a highly efficient no-wash red optical molecular imaging agent that enables the rapid, selective, and specific visualization of Gram-positive bacteria through a bespoke optical fiber-based delivery/imaging endoscopic device.

Methods: We rationally designed a no-wash, red, Gram-positive-specific molecular imaging agent (Merocy-Van) based on vancomycin and an environmental merocyanine dye.

Porous silicon nanocrystals in a silica aerogel matrix.

Silicon nanoparticles of three types (oxide-terminated silicon nanospheres, micron-sized hydrogen-terminated porous silicon grains and micron-size oxide-terminated porous silicon grains) were incorporated into silica aerogels at the gel preparation stage. Samples with a wide range of concentrations were prepared, resulting in aerogels that were translucent (but weakly coloured) through to completely opaque for visible light over sample thicknesses of several millimetres. The photoluminescence of these composite materials and of silica aerogel without silicon inclusions was studied in vacuum and in the presence of molecular oxygen in order to determine whether there is any evidence for non-radiative energy transfer from the silicon triplet exciton state to molecular oxygen adsorbed at the silicon surface.

Guidance in Kagome-like photonic crystal fibres I: analysis of an ideal fibre structure.

Propagation of light in a square-lattice hollow-core photonic crystal fibre is analysed as a model of guidance in a class of photonic crystal fibres that exhibit broad-band guidance without photonic bandgaps. A scalar governing equation is used and analytic solutions based on transfer matrices are developed for the full set of modes. It is found that an exponentially localised fundamental mode exists for a wide range of frequencies.

Large-core acetylene-filled photonic microcells made by tapering a hollow-core photonic crystal fiber.

We report on kagomé-lattice photonic microcells with low losses, large outer diameters, and large cores. The large (40-70microm) cores are accommodated by tapering the fibers and splicing the reduced ends to a single-mode fiber. We demonstrate the repeatability of this process and obtain splice losses of 0.

Characterization of a photonic crystal fiber mode converter using low coherence interferometry.

The relative group delay of the different modes present in an all-fiber LP11 mode converter at a central wavelength of 750 nm is observed using low coherence interferometric imaging. We have simultaneously measured the relative group delay and computed the intensity and the phase distribution of the modes emitted from the mode converter end face using a Fourier technique, providing unequivocal identification of the modes involved.

Approximate band structure calculation for photonic bandgap fibres.

An approximate method for finding the band structure of simple photonic bandgap fibres is presented. Our simple model is an isolated high-index rod in a circular unit cell with two alternative boundary conditions. Band plots calculated this way are found to correspond closely to calculations using an accurate numerical method.