Publications by authors named "Timo Schmidberger"
Article Synopsis
- Genetically-modified therapies like CAR-T are really effective at fighting tough blood cancers but making them is complicated.
- Researchers used a special method called quality-by-design (QbD) to improve how CAR-T cells are made, focusing on things like how many times the cells are turned on and how crowded they are in their growing environment.
- They found that doing a single activation step and growing the cells for a shorter time helped create way more healthy CAR-T cells, which worked just as well when tested on a bigger scale.
The production of biopharmaceuticals requires highly sophisticated, complex cell based processes. Once a process has been developed, acceptable ranges for various control parameters are typically defined based on process characterization studies often comprising several dozens of small scale bioreactor cultivations. A lot of data is generated during these studies and usually only the information needed to define acceptable ranges is processed in more detail.
View Article and Find Full Text PDFMass spectrometry has been frequently applied to monitor the O₂ and CO₂ content in the off-gas of animal cell culture fermentations. In contrast to classical mass spectrometry the proton transfer reaction mass spectrometry (PTR-MS) provides additional information of volatile organic compounds by application of a soft ionization technology. Hence, the spectra show less fragments and can more accurately assigned to particular compounds.
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