Volunteering Experience of the Poor Patient Fund during Medical School.

Unlabelled: Access to healthcare poses significant financial hurdles for economically disadvantaged patients especially in developing countries like Nepal, presenting as one of the most prominent obstacles in ensuring their right to proper medical support. In response to this issue, a student-run organization called, 'Our Attempt Towards Health' has established the poor patient fund to assist those in need. The poor patient fund helps economically deprived patients with their treatment costs by providing them financial assistance and at the same time medical students have the opportunity to volunteer, creating an early and empathetic connection with patients.

Contaminated Water and an Indication of Risk: Examining Microbial Contamination in the Water Used by Consumers and Commercial Growers in Fresh Produce Systems in Nepal.

There has been limited research and understanding of the water quality in developing countries. Fresh produce consumed raw is nutrient-dense but is more susceptible to causing foodborne illness when contaminated water is used in production and consumption. There have been increasing reported incidences of foodborne outbreaks in Nepal linked to fresh produce contamination.

Prevalence of prehypertension and hypertension among the adults in South Asia: A multinomial logit model.

Hypertension has been the most common non-communicable disease in low and middle-income countries for the past two decades, increasing cardiovascular and renal disease risk. Urbanization, aging, dietary and lifestyle changes, high illiteracy rates, poor access to health facilities, poverty, high costs of drugs, and social stress have contributed to an increase in the prevalence of hypertension in developing countries. Nonetheless, little is known about the comprehensive risk factors associated with prehypertension and hypertension among economically active adult populations of South Asia, such as India, Nepal, and Bangladesh.

Imaging retinaldehyde-protein binding in plants using a merocyanine reporter.

Retinoid-binding proteins (RBPs) are a diverse category of proteins that have been most extensively characterized for their role in vertebrate development. Recent work has uncovered new functions of RBPs in invertebrates and plants. Here, we present a methodology for applying a fluorescent chemical probe to characterize RBP binding in plants.

Ethylene responsive factor34 mediates stress-induced leaf senescence by regulating salt stress-responsive genes.

Leaf senescence proceeds with age but is modulated by various environmental stresses and hormones. Salt stress is one of the most well-known environmental stresses that accelerate leaf senescence. However, the molecular mechanisms that integrate salt stress signalling with leaf senescence programmes remain elusive.

ORESARA 15, a PLATZ transcription factor, controls root meristem size through auxin and cytokinin signalling-related pathways.

An optimal size of post-embryonic root apical meristem (RAM) is achieved by a balance between cell division and differentiation. Despite extensive research, molecular mechanisms underlying the coordination of cell division and differentiation are still fragmentary. Here, we report that ORESARA 15 (ORE15), an Arabidopsis PLANT A/T-RICH SEQUENCE-AND ZINC-BINDING PROTEIN (PLATZ) transcription factor preferentially expressed in the RAM, determines RAM size.

Signal Sensitivity Enhancement of High-Spatial-Resolution MR Imaging with a Concatenated Cylindrical Parametric RF-Resonator.

Phased array MRI coils can increase sensitivity of superficial tissues owing to their proximity to the detection region. Deep-lying tissues, on the other hand, do not benefit to the same degree. Here we investigate the use of a localized cylindrically symmetric quadruple frequency resonator concatenated with a double frequency resonator to increase the longitudinal field-of-view (FOV) without compromising the spatial-resolution and detection sensitivity.

Parallel magnetic resonance image reconstruction from a single-element parametric amplifier.

In magnetic resonance imaging (MRI), acquisition speed is always an important issue. In this paper, we propose a promising technique to achieve parallel MRI (pMRI) on a single-channel spectrometer, using a novel Wireless Amplified Nuclear MR Detector (WAND) for spatial encoding in image reconstruction. For this, a planar structure double frequency WAND is designed and fabricated, where two of its frequencies - 'signal', ω and 'idler', ω are effectively utilized as two separate "channels" for accelerated acquisition.

Profile of chlorophylls and carotenoids of wheat ( L.) and barley ( L.) microgreens.

The use of cereal microgreens is increasing because of increased consumer's interest in healthier products. Chlorophyll (Chl) and Carotenoids (Car) are suggested to correlate with health promoting components like phenolics and antioxidant potential of the plant-part. They also play role against clinical conditions like thalassemia and hemolytic anemia and reduce the risk of some chronic diseases, such as cancer, cardiovascular diseases, skin diseases and age-related eye diseases.

Temporal changes in cell division rate and genotoxic stress tolerance in quiescent center cells of Arabidopsis primary root apical meristem.

Plant roots provide structural support and absorb nutrients and water; therefore, their proper development and function are critical for plant survival. Extensive studies on the early stage of ontogenesis of the primary root have revealed that the root apical meristem (RAM) undergoes dynamic structural and organizational changes during early germination. Quiescent center (QC) cells, a group of slowly dividing cells at the center of the stem-cell niche, are vital for proper function and maintenance of the RAM.

Highly efficient power conversion in magnetoelectric gyrators with high quality factor.

A high-Q magnetoelectric (ME) gyrator consisting of a trilayer laminate of nickel-iron-based constant elasticity alloy (Ni-Fe-Cr) and lead zirconate titanate with a coil wound around it has been developed and systematically characterized. Highly efficient magneto-mechanical-electric conversion can be achieved by means of the combination contributions of high quality factors from individuals, and much energy can be transferred through the gyration device. Under an electromechanical resonance frequency of 54.

A Novel Expandable Catheter Wireless Amplified NMR Detector for MR Sensitivity Accessing the Kidney in Rodent Model.

This paper demonstrates the enlarged effective range for MRI sensitivity enhancement with a deformable catheter MRI coils integrated with a wirelessly powered amplifier. The expandable balloon wireless amplified nuclear magnetic resonance detector (WAND) is constructed on a copper-clad polyimide film to resonate at the first and second harmonics of the proton Larmor frequency at 7 Tesla. The WAND is then mounted on a balloon catheter system for easy delivery inside confined orifice.

Self-assembly of multiferroic core-shell composites using DNA functionalized nanoparticles.

Ferrite-ferroelectric core-shell nanoparticles were prepared by deoxyribonucleic acid (DNA) assisted self-assembly and the strained mediated magneto-electric (ME) interactions between the ferroic phases were studied. The nanoparticle type and size were varied and the DNA linker sequence was also varied. Two kinds of particles, one with 600 nm barium titanate (BTO) core and 200 nm nickel ferrite (NFO) shell and another with 200 nm BTO core and 50 nm nickel cobalt ferrite (NCFO) shell were prepared.

ORESARA15, a PLATZ transcription factor, mediates leaf growth and senescence in Arabidopsis.

Plant leaves undergo a series of developmental changes from leaf primordium initiation through growth and maturation to senescence throughout their life span. Although the mechanisms underlying leaf senescence have been intensively elucidated, our knowledge of the interrelationship between early leaf development and senescence is still fragmentary. We isolated the oresara15-1Dominant (ore15-1D) mutant, which had an extended leaf longevity and an enlarged leaf size, from activation-tagged lines of Arabidopsis.

Sustainability of common pool resources.

Sustainability has become a key issue in managing natural resources together with growing concerns for capitalism, environmental and resource problems. We hypothesize that the ongoing modernization of competitive societies, which we refer to as "capitalism," affects human nature for utilizing common pool resources, thus compromising sustainability. To test this hypothesis, we design and implement a set of dynamic common pool resource games and experiments in the following two types of Nepalese areas: (i) rural (non-capitalistic) and (ii) urban (capitalistic) areas.

Strain Doping: Reversible Single-Axis Control of a Complex Oxide Lattice via Helium Implantation.

We report on the use of helium ion implantation to independently control the out-of-plane lattice constant in epitaxial La(0.7)Sr(0.3)MnO(3) thin films without changing the in-plane lattice constants.

Photobiological hydrogen production and artificial photosynthesis for clean energy: from bio to nanotechnologies.

Global energy demand is increasing rapidly and due to intensive consumption of different forms of fuels, there are increasing concerns over the reduction in readily available conventional energy resources. Because of the deleterious atmospheric effects of fossil fuels and the uncertainties of future energy supplies, there is a surge of interest to find environmentally friendly alternative energy sources. Hydrogen (H2) has attracted worldwide attention as a secondary energy carrier, since it is the lightest carbon-neutral fuel rich in energy per unit mass and easy to store.

Pulsed laser-assisted focused electron-beam-induced etching of titanium with XeF2: enhanced reaction rate and precursor transport.

In order to enhance the etch rate of electron-beam-induced etching, we introduce a laser-assisted focused electron-beam-induced etching (LA-FEBIE) process which is a versatile, direct write nanofabrication method that allows nanoscale patterning and editing. The results demonstrate that the titanium electron stimulated etch rate via the XeF2 precursor can be enhanced up to a factor of 6 times with an intermittent pulsed laser assist. The evolution of the etching process is correlated to in situ stage current measurements and scanning electron micrographs as a function of time.

Monte Carlo simulations of nanoscale focused neon ion beam sputtering of copper: elucidating resolution limits and sub-surface damage.

A three dimensional Monte Carlo simulation program was developed to model physical sputtering and to emulate vias nanomachined by the gas field ion microscope. Experimental and simulation results of focused neon ion beam induced sputtering of copper are presented and compared to previously published experiments. The simulation elucidates the nanostructure evolution during the physical sputtering of high aspect ratio nanoscale features.

Fundamental resolution limits during electron-induced direct-write synthesis.

In this study, we focus on the resolution limits for quasi 2-D single lines synthesized via focused electron-beam-induced direct-write deposition at 5 and 30 keV in a scanning electron microscope. To understand the relevant proximal broadening effects, the substrates were thicker than the beam penetration depth and we used the MeCpPt(IV)Me3 precursor under standard gas injection system conditions. It is shown by experiment and simulation how backscatter electron yields increase during the initial growth stages which broaden the single lines consistent with the backscatter range of the deposited material.

Monte Carlo simulations of nanoscale focused neon ion beam sputtering.

A Monte Carlo simulation is developed to model the physical sputtering of aluminum and tungsten emulating nanoscale focused helium and neon ion beam etching from the gas field ion microscope. Neon beams with different beam energies (0.5-30 keV) and a constant beam diameter (Gaussian with full-width-at-half-maximum of 1 nm) were simulated to elucidate the nanostructure evolution during the physical sputtering of nanoscale high aspect ratio features.

Towards a critical understanding of the photosystem II repair mechanism and its regulation during stress conditions.

Photosystem II (PSII) is vulnerable to high light (HL) illumination resulting in photoinhibition. In addition to photoprotection mechanisms, plants have developed an efficient PSII repair mechanism to save themselves from irreversible damage to PSII under abiotic stresses including HL illumination. The phosphorylation/dephosphorylation cycle along with subsequent degradation of photodamaged D1 protein to be replaced by the insertion of a newly synthesized copy of D1 into the PSII complex, is the core function of the PSII repair cycle.

A study of hydrogen microstructure in amorphous silicon via inversion of nuclear magnetic resonance spectra.

We present an inverse approach for studying hydrogen microstructure in amorphous silicon. The approach consists of generating a prior distribution (of spins/hydrogen) by inverting experimental nuclear magnetic resonance (NMR) data, which is subsequently superimposed on a network of amorphous silicon. The resulting network is then relaxed using a total-energy functional to obtain a stable, low-energy configuration such that the initial spin distribution is minimally perturbed.

Synthesis of nanowires via helium and neon focused ion beam induced deposition with the gas field ion microscope.

The ion beam induced nanoscale synthesis of platinum nanowires using the trimethyl (methylcyclopentadienyl)platinum(IV) (MeCpPt(IV)Me3) precursor is investigated using helium and neon ion beams in the gas field ion microscope. The He(+) beam induced deposition resembles material deposited by electron beam induced deposition with very small platinum nanocrystallites suspended in a carbonaceous matrix. The He(+) deposited material composition was estimated to be 16% Pt in a matrix of amorphous carbon with a large room-temperature resistivity (∼3.

A comparison of neon versus helium ion beam induced deposition via Monte Carlo simulations.

The ion beam induced nanoscale synthesis of PtCx (where x ∼ 5) using the trimethyl (methylcyclopentadienyl)platinum(IV) (MeCpPt(IV)Me3) precursor is investigated by performing Monte Carlo simulations of helium and neon ions. The helium beam leads to more lateral growth relative to the neon beam because of its larger interaction volume. The lateral growth of the nanopillars is dominated by molecules deposited via secondary electrons in both the simulations.