[Pharmacogenomic and pharmacometabolomic biomarkers of the efficacy and safety of antidepressants: focus on selective serotonin reuptake inhibitors].

The efficacy and safety of psychopharmacotherapy with antidepressants is of great medical importance. The search for clinical and biological predictors for choosing the optimal psychopharmacotherapy with antidepressants is actively underway all over the world. Research is mainly devoted to searching for associations of polymorphic gene variants with the efficacy and safety of therapy.

Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium.

We provide an overview of the recent achievements in psychiatric genetics research in the Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, and pharmacogenetic studies, with an emphasis on genome-wide association studies. The genetic backgrounds of mental illnesses in the polyethnic and multicultural population of the Russian Federation are still understudied. Furthermore, genetic, genomic, and pharmacogenetic data from the Russian Federation are not adequately represented in the international scientific literature, are currently not available for meta-analyses and have never been compared with data from other populations.

[Integrated assessment of educational conditions in general education establishments of different types].

The integrated assessment of urban general educational establishments has revealed that teaching conditions at most of them do not meet the requirements of hygiene and the natural science bases of age-related psychophysiology. Only at the recently commissioned schools, the teaching conditions are recognized to be acceptable and they may become optimal on remedying flaws in the organization of a teaching-and-educational process. The conditions at other earlier built schools are moderately hazardous.

[Hygienic assessment of organization of an educational process in the general education establishments of a large town].

The mental health status of a rising generation is a necessary condition for acquiring professional knowledge and work skills and socializing the personality. In the opinion of many investigators, schoolchildren's mental health maintenance depends on the correct organization of a teaching process and on the observance of the hygienic academic work standards to a large measure. The assessment of organization of a teaching process at different types of urban general educational establishments has revealed a number of failures to observe the sanitary-and-epidemiological regulations and standards of SanPin 2.