Publications by authors named "Timea Kuik-Rozsa"
Biophysical characterization of histone H3.3 K27M point mutation.
Biochem Biophys Res Commun
August 2017
Lysine 27 to methionine (K27 M) mutation of the histone variant H3.3 drives the formation of an aggressive glioblastoma multiforme tumor in infants. Here we analyzed how the methionine substitution alters the stability of H3.
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- Scientists studied how R-loops (which are like a mix of DNA and RNA) affect chromosomes and diseases.
- They focused on improving a method called DRIP to measure these R-loops better, but found some problems and errors in the original way it was done.
- After testing different techniques, they created a new, better method that helps scientists accurately find and study R-loops without mixing up the results.