Sulfated galactofucan from seaweed attenuates proteolytic enzyme dipeptidyl-peptidase-4: a potential anti-hyperglycemic lead.

Dipeptidyl-peptidase-4 is a multifunctional ectoenzyme, which is implicated with hyperglycemic pathophysiology. Therefore, dipeptidyl-peptidase-4 inhibitors could be used as an attractive therapeutic strategy in blood-glucose homeostasis to attenuate the pathophysiologies of diabetes. A sulfated galactofucan characterized as [→1)--4-sulfonato--fucopyranosyl-(2→1)--2-sulfonato--fucopyranose-(3→] along with a branch of [→1)-6--methyl--galactopyranosyl-(4→] unit at the C-4 position of -2-sulfonato--fucopyranose, isolated from the seaweed , exhibited prospective attenuation property against dipeptidyl-peptidase-4 (IC 0.

Marine Macroalgal Polygalactan-Built Nanoparticle Construct for Osteogenesis.

Naturally derived polysaccharide biopolymer-based nanoparticles with their size and drug release potentials have appeared as promising biomaterials for osteogenic differentiation. A metallic nanoparticle (GS-AgNP) prepared from a sulfated polygalactan characterized as →3)-2--methyl--6-sulfonato-β-d-galactopyranosyl-(1 → 4)-2--methyl-3,6-anhydro-α-d-galactopyranose-(1→ isolated from the marine macroalga exhibited a prospective osteogenic effect. Upon treatment with the studied GS-AgNP, alkaline phosphatase activity (88.

Salicornolides A-C from Gracilaria salicornia attenuate pro-inflammatory 5-lipoxygense: Prospective natural anti-inflammatory leads.

Three macrolides bearing the carbon framework of oxabicyclo[21.3.1]heptacosa-ene-diones (A and B) and oxabicyclo[19.

First report of spiro-compounds from marine macroalga : prospective natural anti-inflammatory agents attenuate 5-lipoxygenase and cyclooxygenase-2.

The inflammation pathology is an orchestrated biological process and the dual inhibition of pro-inflammatory enzymes 5-lipoxygenase and cyclooxygenase-2 has been found to be an effective approach against inflammation. This study involves the characterisation of two previously undescribed spiro[5.5]undecanes, 3-(hydroxymethyl)-7-(methoxymethyl)-3,11-dimethyl-9-oxospiro[5.

Antioxidative dolabellanes and dolastanes from brown seaweed as dual inhibitors of starch digestive enzymes.

New dolabellanes {6-methoxy-dolabella-8(17),12-diene-10,18-diol (), 3-methoxy-dolabella-12(18)-ene-4-ol (), 3-methoxy-dolabella-10,18(19)-diene-5,8-diol ()} and dolastanes {2,7-dimethoxy-14-hydroxy-dolasta-1(15),9-diene () and 4,7-dimethoxy-9,14-dihydroxy-dolasta-1-ene ()} were identified from brown seaweed (family Dictyotaceae), collected from the southeast coast of India. Compounds - were found to possess dolabellane skeleton with [9.3.

First report of antioxidative -chromenyl derivatives from the intertidal red seaweed as potential anti-inflammatory agents.

Phytochemical investigation on biologically active compounds of an intertidal red seaweed (family Gracilariaceae) guided to the separation of two previously undisclosed -chromenyl derivatives. The compounds were characterised as 4'-[10'-[7-hydroxy-2,8-dimethyl-6-(pentyloxy)-2-chromen-2-yl]ethyl]-3',4'-dimethyl-cyclohexanone () and 3'-[10'-(8-hydroxy-5-methoxy-2,6,7-trimethyl-2-chromen-2-yl)ethyl]-3'-methyl-2'-methylene cyclohexyl butyrate () by extensive spectroscopic experiments. The studied metabolites recorded prospective bioactivities against 5-lipoxygenase (IC < 2.

First report of antioxidant abeo-labdane type diterpenoid from intertidal red seaweed with 5-lipoxygenase inhibitory potential.

Phytochemical investigation on the biologically active compounds of seaweed {(C. Agardh) E.Y.