Publications by authors named "Tim Mickan"
Post-traumatic joint stiffness (PTJS) is accompanied by a multidimensional disturbance of joint architecture. Pharmacological approaches represent promising alternatives as the traumatic nature of current therapeutic standards may lead to PTJS' progression. Losartan is an auspicious candidate, as it has demonstrated an antifibrotic effect in other organs.
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- The study examined the effects of atorvastatin on posttraumatic joint contracture using a rat model, involving 48 rats divided into atorvastatin and control groups.
- Despite atorvastatin reducing the number of myofibroblasts and collagen in the joint capsule, it did not significantly improve joint mobility or prevent contracture formation.
- The findings indicate that the primary cause of joint contracture was arthrogenic, and atorvastatin's antifibrotic properties did not translate into better joint function in this context.
Background: After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic joint stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems.
Objective: The purpose of this study was the evaluation of the influence of losartan and atorvastatin on the early development of joint contracture.