Novel Long Noncoding RNA Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing.

Background: Activation of the immune system contributes to cardiovascular diseases. The role of human-specific long noncoding RNAs in cardioimmunology is poorly understood.

Methods: Single-cell sequencing in peripheral blood mononuclear cells revealed a novel human-specific long noncoding RNA called (heart failure-associated transcript 4).