Publications by authors named "Tim M H Li"

Article Synopsis
  • - This study is the first to investigate the effectiveness and safety of transcranial pulse stimulation (TPS) as a treatment for ADHD in young adolescents (ages 12-17) in Hong Kong.
  • - Conducted as a double-blind, randomized, sham-controlled trial with 30 ADHD-diagnosed participants, evaluations were made before and after TPS treatment as well as at 1 and 3-month follow-ups.
  • - Results showed that the TPS group had a consistent 30% reduction in ADHD symptoms, as measured by SNAP-IV scores, indicating that TPS is a promising and safe add-on treatment for managing ADHD.
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There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to record rest-activity, facial expression, voice, and mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], and Artificial Neural Networks [ANN]) with leave-one-out cross-validation were applied to detect lifetime diagnosis of MDD and non-remission status.

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Purpose Of Review: Social media use (SMU) and other internet-based technologies are ubiquitous in today's interconnected society, with young people being among the commonest users. Previous literature tends to support that SMU is associated with poor sleep and mental health issues in youth, despite some conflicting findings. In this scoping review, we summarized relevant studies published within the past 3 years, highlighted the impacts of SMU on sleep and mental health in youth, while also examined the possible underlying mechanisms involved.

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Study Objectives: This study examines the (dis)agreement between objective and subjective sleep and their prospective changes in a randomized controlled trial of bright light therapy (BLT) in patients with major depressive disorder (MDD) and eveningness.

Methods: A total of 93 adults were randomized to receive either 30-min daily of 10,000 lux BLT or 50lux placebo dim red light therapy (DRL group) for a total of 5 weeks. Actigraphic data were collected at the baseline and during the last week of treatment.

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Transcranial pulse stimulation has been proven effective to improve cognition, memory and depressive symptoms of Alzheimer's disease, but supporting evidence on other neurological diseases or neuropsychiatric disorders remains limited. This study aimed to investigate the effects of transcranial pulse stimulation on the right temporoparietal junction, which is a key node for social cognition for autism spectrum disorder, and to examine the association between transcranial pulse stimulation and executive and social functions. This double-blinded, randomized, sham-controlled trial included 32 participants (27 males), aged 12-17 years with autism spectrum disorder.

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The prevalence of symptoms of anxiety is increasing, especially during the COVID-19 pandemic. A home use transdermal neurostimulation device might help to minimize the severity of anxiety disorder. To the best of our knowledge, there is no clinical trial using transdermal neurostimulation to treat individuals with symptoms of anxiety in Asia.

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Insomnia is a common health problem in the general population. There are different ways to improve sleeping habits and quality of sleep; however, there is no clinical trial using transdermal neurostimulation to treat individuals with symptoms of insomnia in Asia. This gives us the impetus to execute the first study in Asia which aims to evaluate the efficacy of Electrical Vestibular Stimulation (VeNS) on individuals with insomnia in Hong Kong.

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Objective: Sensorimotor performance is influential in Chinese handwriting, but few studies have examined the efficacy of sensorimotor-based interventions on Chinese handwriting among primary school students with poor handwriting performance. The study aims to evaluate a sensorimotor-based intervention to improve handwriting in the mainstream primary schools.

Methods: This study adopted a two-group pretest-posttest design.

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Article Synopsis
  • - Transcranial pulse stimulation (TPS) has shown promise in enhancing cognitive functions in Alzheimer’s patients, but its effectiveness for major depressive disorder (MDD) had not been previously tested on a wide scale until this trial.
  • - In a 2-week study with 30 participants aged 18-54, who were split into a TPS group and a waitlist control group, results indicated a significant reduction in depressive symptoms for those receiving TPS therapy as measured by the Hamilton depression rating scale-17.
  • - The findings revealed that TPS not only effectively reduced depression severity but also showed strong and lasting effects observed during a follow-up three months post-treatment.
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Study Objectives: This study aimed to examine the effect of sleep-corrected social jetlag (SJLsc) on mental health, behavioral problems, and daytime sleepiness in adolescents.

Methods: This was a cross-sectional study which included 4787 adolescents (Mean age: 14.83±1.

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Background: Electronic media use (EMU) becomes one of the most common activities in adolescents. The present study investigated the deleterious influence of excessive EMU and EMU before bedtime on social, emotional, and behavioral difficulties (SEBD) in adolescents. The role of sleep and circadian problems in mediating the association of EMU with SEBD was examined.

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Background: "Horizontal strokes should be level and vertical strokes should be straight" is a common guideline in the teaching of Chinese handwriting. Measuring deviations in level horizontal and straight vertical strokes in students' Chinese handwriting is usually assessed manually. However, this task is time-consuming and may have inconsistent outcomes when judged by different people.

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Background/aim: Handwriting difficulties can be detrimental to students' performance in school tests and even in public examinations. It is crucial for school-based occupational therapists to identify students with handwriting difficulties and support them with appropriate adaptive strategies. The purpose of this study is to validate a computerised assessment - the Computerised Handwriting Speed Test System (CHSTS) of both Chinese and English handwriting for Chinese secondary students and provide an objective reference for extra time allowance in paper-based examinations.

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Although fathers actively provide infant care and support to their partners in modern societies, data on fathers' difficulties and mental health problems is still limited. This study examined paternal postpartum depression and its adverse impact on infants, and the possible mediating role of father-infant attachment in the link between fathers' depressive symptoms and infants' outcomes. Pregnant women and their partners were recruited from the antenatal clinics of two public hospitals in Hong Kong.

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Objectives: Attention deficit hyperactivity disorder (ADHD) and learning difficulties (LDs) are proposed as 2 overlapping disorders. The objective of this study was to investigate the handwriting performance in ADHD and comorbid ADHD-LD adolescents.

Methods: The study examined the Chinese and English handwriting performance and sensorimotor skills of 32 ADHD, 12 ADHD-LD, and their matched controls.

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Impaired sensorimotor control, as a common feature of autism spectrum disorder (ASD), could be a driving factor to handwriting problems. This study examined the Chinese and English handwriting and sensorimotor skills of 15 ASD and 174 typically developing Chinese adolescents. Participants with ASD had lower writing speed and poor manual dexterity (MD) than the typically developing participants.

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Aim: The aim of this study was to explore the online distress and help-seeking behavior of youths in Hong Kong.

Methods: A cross-sectional telephone-based survey was conducted among 1,010 young people in Hong Kong. Logistic regression analysis was then performed to identify the factors associated with those who reported expressing emotional distress online and the differences in help-seeking behavior among four groups of youths: (1) the non-distressed (reference) group; (2) "Did not seek help" group; (3) "Seek informal help" group; and (4) "Seek formal help" group.

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Objectives: The present study aimed to examine the trends and characteristics of fall-related attendance in accident and emergency department (AED) by injury type and the trend in associated average length of stay (LOS) among children and adolescents in Hong Kong.

Design: A retrospective approach was adopted.

Setting: AED, involving all local public emergency departments from 2001 to 2012.

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Background: Depression prevention among adolescents is crucial for reducing the global disease burden. Internet-based depression prevention approaches are found to be effective but they were mostly evaluated in a Western context. Grasping the Opportunity is a Chinese Internet intervention, which was translated and modified from CATCH-IT developed in the West.

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Article Synopsis
  • Hikikomori is a significant issue in Japan, identified as long-term adolescent social withdrawal, leading to clinical impairments for youths and burdens on families.
  • Cases of social withdrawal have also been reported in other countries, but these youths can be difficult to identify due to their secluded nature.
  • The editorial emphasizes the need for more research on youth social withdrawal to better understand its causes and potential solutions, aiming to raise awareness in middle- and high-income countries.
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