Publications by authors named "Tim M Crozier"

Article Synopsis
  • Activin A is a protein linked to muscle loss, and its levels rise during critical illness; this study aimed to examine how these elevated levels relate to muscle strength and physical function in ICU patients.
  • In a study with 36 critically ill participants from two ICUs, higher levels of activin A were found to correlate with poorer performance on a key measure of physical function (the Six-Minute Walk Test) at the time of hospital discharge.
  • The results suggest that increased activin A might indicate functional decline in these patients, highlighting the need for further research into its potential role in treatment and muscle health during severe illness.
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Background: The incidence of severe acute maternal morbidity (SAMM) is one method of measuring the complexity of maternal health and monitoring maternal outcomes. Monitoring trends may provide a quantitative method for assessing health care at local, regional, or jurisdictional levels and identify issues for further investigation.

Aims: Identify temporal trends for SAMM event rates and maternal outcomes over 17 years in the state of Victoria, Australia.

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Background: Atrial fibrillation (AF) occurs frequently following cardiothoracic surgery and treatment decisions are informed by evidence-based clinical guidelines. Outside this setting there are few data to guide clinical management.

Aim: To describe the characteristics, management and outcomes of hospitalised adult patients with new-onset AF.

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Background: Despite the high mortality in patients with pneumonia admitted to an ICU, data on risk factors for death remain limited.

Methods: In this secondary analysis of PROTECT (Prophylaxis for Thromboembolism in Critical Care Trial), we focused on the patients admitted to ICU with a primary diagnosis of pneumonia. The primary outcome for this study was 90-day hospital mortality and the secondary outcome was 90-day ICU mortality.

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Objective: To determine how frequently stress ulcer prophylaxis (SUP) medications prescribed in the intensive care unit are inappropriately continued on the ward and on hospital discharge.

Design: Retrospective cohort study; chart review.

Setting: Two Australian ICUs: one tertiary centre and one metropolitan centre.

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Objective: To determine how frequently stress ulcer prophylaxis (SUP) medications prescribed in the intensive care unit are inappropriately continued on the ward and on hospital discharge.

Design: Retrospective cohort study; chart review.

Setting: Two Australian ICUs: one tertiary centre and one metropolitan centre.

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Background: In a recent multicenter randomized trial comparing unfractionated heparin (UFH) with low-molecular-weight heparin (dalteparin) for thromboprophylaxis in 3,746 critically ill patients, 17 patients (0.5%) developed heparin-induced thrombocytopenia (HIT) based on serotonin-release assay-positive (SRA+) status. A trend to a lower frequency of HIT with dalteparin vs UFH was observed in the intention-to-treat analysis (five vs 12 patients, P = .

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Background: Monash Medical Centre (MMC) is a university-affiliated tertiary referral hospital in Melbourne, Victoria, Australia. The hospital has a large obstetric service and is the only quarternary obstetric unit in Victoria. The intensive care unit (ICU) is a busy 21-bed general unit with a broad casemix.

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Aim And Methods: There is no consensus definition on what constitutes a long stay in the intensive care unit, and little published information on the demographic characteristics, resource usage or outcomes of long-stay patients. We used data from the Australian and New Zealand Intensive Care Society Adult Patient Database to identify patients who had spent > 21 days in the ICU. We examined their resource usage, hospital type, diagnoses and outcomes, and trends in these characteristics over 5 years (2000-2004).

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