In vitro release and bioaccessibility of oral solid preparations in a dynamic gastrointestinal system simulating fasted and fed states: A case study of metformin hydrochloride tablets.

Food and formulation characteristics are crucial factors affecting the gastrointestinal release and absorption kinetics of oral solid preparations. In the present study, the dynamic continuous release and bioaccessibility of metformin hydrochloride immediate-release (IR) and sustained-release (SR) tablets were investigated in the dynamic human stomach-intestine (DHSI-IV) system simulating fasted and fed states in healthy adults. Both tablet formulations (particularly IR tablet) exhibited a postponed release in the fed state compared to the fasted state.

Extending Porous Silicone Capacitive Pressure Sensor Applications into Athletic and Physiological Monitoring.

Porous polymer dielectric materials have been developed to increase the sensitivity of capacitive pressure sensors, so that they might expand capacitive sensor use, and promote the realization of the advantages of this class of sensor in further fields. However, their use has not been demonstrated in physiological monitoring applications such as respiration monitoring and body position detection during sleep; an area in need of unmet medical attention for conditions such as sleep apnea. Here, we develop and characterize a sensor comprised of a poly dimethylsiloxane (PDMS) sponge dielectric layer, and PDMS/carbon black (CB) blend electrode layers, with suitable compliance and sensitivity for integration in mattresses, pillows, and athletic shoe insoles.

Practical and Durable Flexible Strain Sensors Based on Conductive Carbon Black and Silicone Blends for Large Scale Motion Monitoring Applications.

Presented is a flexible capacitive strain sensor, based on the low cost materials silicone (PDMS) and carbon black (CB), that was fabricated by casting and curing of successive silicone layers-a central PDMS dielectric layer bounded by PDMS/CB blend electrodes and packaged by exterior PDMS films. It was effectively characterized for large flexion-angle motion wearable applications, with strain sensing properties assessed over large strains (50%) and variations in temperature and humidity. Additionally, suitability for monitoring large tissue deformation was established by integration with an in vitro digestive model.