Publications by authors named "Tim J C Bruxner"
Article Synopsis
- An integrated genomic study of 456 pancreatic ductal adenocarcinomas identified 32 mutated genes organized into 10 key pathways affecting cancer development.
- The analysis categorized the tumors into four distinct subtypes: squamous, pancreatic progenitor, immunogenic, and aberrantly differentiated endocrine exocrine (ADEX), each linked to unique histopathological traits.
- Findings indicate that squamous tumors have poor prognosis and specific mutations, pancreatic progenitor tumors express developmental genes, ADEX tumors are linked to KRAS activation, and immunogenic tumors involve immune suppression networks, suggesting diverse molecular pathways for potential treatments.
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2).
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