Exploring the combinatorial explosion of amine-acid reaction space via graph editing.

Amines and carboxylic acids are abundant chemical feedstocks that are nearly exclusively united via the amide coupling reaction. The disproportionate use of the amide coupling leaves a large section of unexplored reaction space between amines and acids: two of the most common chemical building blocks. Herein we conduct a thorough exploration of amine-acid reaction space via systematic enumeration of reactions involving a simple amine-carboxylic acid pair.

Exploring Future Research in Physical Education: Espousing a Social Justice Perspective.

Although there has been forward movement in identifying and addressing diverse learning needs, social justice education is not a significant part of the current standards for beginning teachers or K-12 students in the U.S. Throughout our standards-based history, social justice has been more of a hidden curriculum.

Magnetic resonance in porous media: recent progress.

Recent years have seen significant progress in the NMR study of porous media from natural and industrial sources and of cultural significance such as paintings. This paper provides a brief outline of the recent technical development of NMR in this area. These advances are relevant for broad NMR applications in material characterization.

Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy.

Objective: To determine the effects of renal osteodystrophy (ROD) on bone microarchitecture in growing rats.

Methods: A total of 24 rats underwent 5/6 nephrectomy (NX) and were fed a high-phosphorus diet to induce ROD; another 6 underwent sham NX. In vitro microcomputed tomography images (GEMS, London, Ontario, Canada) were obtained in the femoral metaphysis and midshaft.

Experimental and computational analyses of the effects of slice distortion from a metallic sphere in an MRI phantom.

Susceptibility artifacts due to metallic prostheses are a major problem in clinical magnetic resonance imaging. We theoretically and experimentally analyze slice distortion arising from susceptibility differences in a phantom consisting of a stainless steel ball bearing embedded in agarose gel. To relate the observed image artifacts to slice distortion, we simulate images produced by 2D and 3D spin-echo (SE) and a view angle tilting (VAT) sequence.

MRI can identify high intensity bands around implants that correspond to radiolucent lines on radiographs: an ex vivo study of sheep acetabula.

We investigated the use of magnetic resonance imaging in categorizing the tissue interface between bone and bone cement after total hip replacement. In an ex vivo sheep model, we compared correlations between the thicknesses of radiolucent lines measured from plain radiographs and corresponding high signal intensity bands in magnetic resonance imaging scans. Correlations obtained for the three main Gruen Zones were in the range between r2 = 0.