Familial amyloid polyneuropathy associated with the novel transthyretin variant Arg34Gly.

We report a 57-year-old man with pathognomonic bilateral vitreo-lenticular amyloid opacities (pseudopodia lentis) in whom a novel transthyretin (TTR) mutation was identified. The patient presented due to bilateral floaters. The vitreous cavities of both eyes showed course, fibrilar opacities attached to the posterior lens surface with pseudopodia.

Vogt-Koyanagi-Harada disease, diabetes mellitus, and psoriasis in a child.

Purpose: To report a case of a child with near-simultaneous onset of Vogt Koyanagi Harada disease (VKH) and insulin-dependent diabetes mellitus (IDDM).

Design: Interventional case report.

Methods: An 11-year-old child with known psoriasis presented with headache and bilateral granulomatous panuveitis.

Thioflavin T fluorescence in human serum: correlations with vascular health and cardiovascular risk factors.

Objectives: Amyloid fibrils and amyloid-like structures are implicated in atherosclerosis via macrophage activation and inflammation. A common property of amyloid-like structures is their ability to induce thioflavin T (ThT) fluorescence. We measured ThT fluorescence in serum and related these levels to traditional cardiovascular risk factors and non-invasive measures of vascular dysfunction (elasticity).