Publications by authors named "Tim Gingerich"
Article Synopsis
- - MAPK pathways play a crucial role in translating external signals into changes in gene expression, with immediate-early genes (IEGs) like fos showing rapid expression after growth factor stimulation.
- - AU-rich binding proteins (AUBPs) such as HuR stabilize fos mRNA, while KSRP counteracts this stabilization; the interplay between these proteins is influenced by the activation of p38 MAPK.
- - The study highlights that p38 MAPK impacts fos mRNA stability by phosphorylating HuR and interacting with protein phosphatase 2 (PP2A) inhibitors, suggesting complex regulatory mechanisms of gene expression in response to cellular signals.
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