Publications by authors named "Tim Bui"

Background: Various methods for measuring intrathecal pressure (ITP) after spinal cord injury (SCI) to guide hemodynamic management have been investigated. To synthesize the current literature, this current study conducted a scoping review of the use of intrathecal devices to monitor ITP during acute management of SCI with the aim of understanding the association between ITP monitoring with physiological and clinical outcomes.

Methods: A systematic review of literature following the Cochrane Handbook for Systematic Reviews of Interventions and Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement.

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  • The text reviews the increasing application of artificial intelligence (AI) in spine surgery, highlighting its roles in the preoperative, intraoperative, and postoperative stages.
  • AI contributes to image analysis, patient diagnosis, and decision-making before surgery, aids navigation during surgery, and helps predict outcomes after surgery.
  • The review also discusses ethical concerns regarding AI's use in healthcare, suggesting that making industry data more transparent could improve trust and patient care.
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Background: The accurate and safe positioning of cervical pedicle screws is crucial. While augmented reality (AR) use in spine surgery has previously demonstrated clinical utility in the thoracolumbar spine, its technical feasibility in the cervical spine remains less explored.

Purpose: The objective of this study was to assess the precision and safety of AR-assisted pedicle screw placement in the cervical spine.

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  • This study is a systematic review that compares two surgical techniques for correcting cervical deformities: anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF).
  • The meta-analysis included 26 studies involving over 25,000 patients, focusing on clinical outcomes like pain scores, radiographic measurements, and various surgical metrics such as complications and recovery time.
  • The findings suggest that while both techniques improve patient outcomes, ACDF shows advantages in reducing neck pain, improving spinal alignment, decreasing graft complications, and lowering surgery duration and hospital stay compared to ACCF.
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  • Various surgical techniques exist for thoracic corpectomy, but traditional posterior methods may not be adequate for complex deformities; this text discusses a transdural multilevel high thoracic corpectomy method.
  • A 25-year-old patient with neurofibromatosis experienced complications after previous surgeries, leading to a novel transdural approach to successfully resect part of the vertebral body.
  • The surgery corrected kyphosis, demonstrated stable neuromonitoring, and showed no postoperative complications after one year, highlighting the effectiveness of the transdural approach for difficult thoracic cases.
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: Advances in virtual reality (VR), augmented reality (AR), and mixed reality (MR) technologies have resulted in their increased application across many medical specialties. VR's main application has been for teaching and preparatory roles, while AR has been mostly used as a surgical adjunct. The objective of this study is to discuss the various applications and prospects for VR, AR, and MR specifically as they relate to spine surgery.

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: Augmented reality head-mounted display (AR-HMD) is a novel technology that provides surgeons with a real-time CT-guided 3-dimensional recapitulation of a patient's spinal anatomy. In this case series, we explore the use of AR-HMD alongside more traditional robotic assistance in surgical spine trauma cases to determine their effect on operative costs and perioperative outcomes. : We retrospectively reviewed trauma patients who underwent pedicle screw placement surgery guided by AR-HMD or robotic-assisted platforms at an academic tertiary care center between 1 January 2021 and 31 December 2022.

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The D-group cyclins play a key role in the progression of cells through the G(1) phase of the cell cycle. Treatment of MCF-7 breast cancer cells with the cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) results in rapid down-regulation of cyclin D1 protein expression and growth arrest in the G(0)/G(1) phase of the cell cycle. 15d-PGJ(2) also down-regulates the expression of cyclin D1 mRNA; however, this effect is delayed relative to the effect on cyclin D1 protein levels, suggesting that the regulation of cyclin D1 occurs at least partly at the level of translation or protein turnover.

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