CD147 and matrix-metalloproteinase-2 expression in metastatic and non-metastatic uveal melanomas.

Background: Extracellular matrix remodelling regulated by matrix-metalloproteinase (MMP) inducer (CD147) is a crucial process during tumor cell invasion and regulation of blood supply. In this study, we evaluated the correlation of CD147 and MMP-2 expression with major prognostic factors for uveal melanoma and the development of metastasis.

Methods: The expression of CD147 and MMP-2 was analyzed in 49 samples of uveal melanomas.