Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT.

Background: Problems in children's early social and emotional development are likely to have major long-term consequences for the individual and society: maternal emotional well-being is associated with better outcomes. Interventions designed to improve both maternal mental health and the mother-child relationship are thus likely to benefit both maternal health and child development.

Objectives: To establish the clinical and cost-effectiveness of the Mellow Babies parenting intervention for women experiencing psychosocial stress and their 6- to 18-month-old babies.

Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay.

Quantitative reverse transcription PCR (qRT-PCR) is a valuable tool for characterizing the effects of inhibitors on viral replication. The amplification of target viral genes through the use of specifically designed fluorescent probes and primers provides a reliable method for quantifying RNA. Due to reagent costs, use of these assays for compound evaluation is limited.

Health of caravan park residents: a pilot cross-sectional study in the East Riding of Yorkshire.

Long-stay coastal caravan communities are common in Britain and anecdotal evidence suggests a high level of socio-economic deprivation, and substantial health needs. A pilot cross-sectional study of English caravan communities in Yorkshire found very high rates of poor health and limiting long-term illness compared with regional and national data and exceeding rates explained by demography and deprivation alone. These insights into previously overlooked health inequalities warrant concern and merit further research and intervention to address them.

A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.

During our ongoing efforts to develop a small molecule inhibitor targeting the beta-amyloid cleaving enzyme (BACE-1), we discovered a class of compounds bearing an aminoimidazole motif. Initial optimization led to potent compounds that have high Pgp efflux ratios. Crystal structure-aided design furnished conformationally constrained compounds that are both potent and have relatively low Pgp efflux ratios.

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.

We have developed a novel series of heteroaromatic BACE-1 inhibitors. These inhibitors interact with the enzyme in a unique fashion that allows for potent binding in a non-traditional paradigm. In addition to the elucidation of their binding profile, we have discovered a pH dependent effect on the binding affinity as a result of the intrinsic pK(a) of these inhibitors and the pH of the BACE-1 enzyme binding assay.

Opportunities for prevention of 'clinically significant' knee pain: results from a population-based cross sectional survey.

Background: There is little UK-based evidence on the prevalence and predictors of knee pain associated with disability across all adult ages. We aimed to estimate the prevalence of 'clinically significant' knee pain, identify and assess the population impact of independent risk factors, and estimate levels of healthcare need.

Methods: A cross-sectional survey of three general practice populations was conducted.

What if my back breaks? Making sense of musculoskeletal pain among South Asian and African-Caribbean people in the North West of England.

Objectives: The pain and disability, which arise as a result of musculoskeletal conditions, have been central to theories and understanding about chronic illness. However, little attention has been paid to the experience of such pain amongst ethnic minority groups. In this paper, we explore Asian and African-Caribbean respondents' ideas about the nature of and management of widespread pain.

Prevalence and predictors of intense, chronic, and disabling neck and back pain in the UK general population.

Study Design: Multiphase cross-sectional survey of musculoskeletal pain.

Objectives: To estimate the prevalence of all reported and clinically significant spinal pain. To identify independent predictors of spinal pain.