Publications by authors named "Tim A O Muntslag"
Microglia are the brain's resident macrophages, which guide various developmental processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the telencephalic wall by the 4th postconceptional week and colonise the fetal brain in a manner that spatiotemporally tracks key neurodevelopmental processes in humans. However, much of what we know about how microglia shape neurodevelopment comes from rodent studies.
View Article and Find Full Text PDFMicroglia, the brain's resident macrophages, shape neural development and are key neuroimmune hubs in the pathological signatures of neurodevelopmental disorders. Despite the importance of microglia, their development has not been carefully examined in the human brain, and most of our knowledge derives from rodents. We aimed to address this gap in knowledge by establishing an extensive collection of 97 post-mortem tissues in order to enable quantitative, sex-matched, detailed analysis of microglia across the human lifespan.
View Article and Find Full Text PDFArticle Synopsis
- In Alzheimer's disease, microglia (a type of brain cell) multiply a lot, which makes the disease get worse faster.
- Researchers found that this rapid multiplication can lead to changes in how these cells behave, causing them to become less effective and contributing to brain damage.
- Stopping the early multiplication of microglia can help prevent some of the damage and build-up of harmful substances in the brain.