Novel dry powder inhalation system based on dispersion of lyophilisates.

Dry powder inhalers and dry powder formulations experience a growing interest and are the subject of continuous further development. In this study the objective was to evaluate the possible aerosolization of lyophilisates by an air impact and to prove this new concept of creating individual inhalable particles from a coherent bulk at the time of inhalation. Therefore an output test system for disintegration of the lyophilisate and for delivery of the generated fine particles was developed.