Bacteremia in a Swedish university hospital: a one-year prospective study in 1981 and a comparison with 1975-76.

A one-year prospective study of bacteremia was carried out at a Swedish university hospital. Blood cultures were taken in 6.3% of all patients admitted to the hospital.

Renal transplant wound infection: the value of prophylactic antibiotic treatment.

The incidence of wound infection after 310 renal transplant operations was examined. Among the 78 recipients not given prophylactic antibiotic therapy infection of the transplant wound occurred in 25.6%.

Studies of cytomegalovirus infection in renal allograft recipients. II. Serological response to various viral antigens.

In a prospective study the antibody response to various cytomegalovirus (CMV) antigens was examined in 28 renal allograft recipients. Both primary and secondary infections were investigated. Antibodies against immediate early (IEA) and early antigens (EA) were studied by anti-complement immunofluorescence; IgM and IgG antibodies to nuclear late antigens were differentiated by enzyme-linked immunosorbent assay (ELISA).

Studies of cytomegalovirus infection in renal allograft recipients.

A prospective study of cytomegalovirus (CMV) infections has been carried out in 28 renal graft recipients. The protocol called for frequent blood and urine sampling during the first year after transplantation, but death or graft loss caused earlier termination in nearly half the patients. In this material 5/7 (71%) susceptible patients developed primary infections and 20/21 experienced a secondary infection (95%).

The effect of immunosuppressive therapy on the phagocytic and metabolic functions of the reticuloendothelial system in renal transplant recipients.

The object of this study was to examine the bearing that immunosuppressive therapy may have on the phagocytic and metabolic functions of the reticuloendothelial system (RES). The phagocytic and metabolic activities of the RES were determined in renal graft recipients before transplantation and at intervals afterwards. The activities were measured as the plasma clearance rate of 125I-labelled microaggregated human serum albumin and the increase in the plasma metabolites of this test substance.

Reticuloendothelial function in human renal allograft recipients.

The phagocytic and metabolic functions of the reticuloendothelial system (RES) were determined, by measuring the plasma clearance rate of 125I-labelled microaggregated human serum albumin and the increase in plasma metabolites of this test substance, in patients with chronic renal failure and in renal transplant recipients at different times after transplantation. All transplant recipients received triple immunosuppressive therapy consisting of azathioprine, corticosteroids, and antilymphocyte globulin. The intravascular clearance of microaggregated albumin was significantly depressed in patients when tested at 1 to 12 days (P less than 0.