Neuropsychological deficits have only limited impact on psychological well-being in amyotrophic lateral sclerosis.

Objective: To investigate the association between neuropsychological deficits and psychological well-being in amyotrophic lateral sclerosis (ALS).

Methods: Subjective (Schedule for the Evaluation of the Individual Quality of Life-Direct Weighting, SEIQoL-DW) and global quality of life (QoL; Anamnestic Comparative Self-Assessment, ACSA) as well as depression (ALS-Depression-Inventory, ADI-12) as indicators for psychological well-being were measured in 214 patients with ALS and correlated with neurocognitive performance assessed by the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Primary caregivers evaluated behaviour.