Publications by authors named "Tilenka R J Thynne"
A Cross-Sectional Study of Capillary Blood Ketone Concentrations in Heart Failure Based on Sodium-Glucose Co-Transporter-2 Inhibitor Use and Heart Failure Type.
Heart Lung Circ
November 2024
Article Synopsis
- Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are commonly used in treating heart failure (HF), but their association with ketosis risk during hospitalization is uncertain.
- A study measured ketone levels in hospitalized patients with worsening HF and stable HF to determine if SGLT2i use influenced ketone concentrations.
- Results showed that ketone levels were low across all patients, regardless of SGLT2i use or the severity of heart failure, indicating minimal risk of ketosis in these individuals.
The aims of this study were to characterise the population pharmacokinetics of metformin in patients receiving haemodialysis, and to determine the doses that will maintain median metformin plasma concentrations below 5 mg L for a typical individual. Metformin plasma concentrations from 5 patients receiving thrice weekly intermittent haemodialysis followed by metformin 500 mg postdialysis were fitted to a published pharmacokinetic model. Additional models to describe the dialytic pharmacokinetics of metformin were explored.
View Article and Find Full Text PDFWith the increasing prevalence of type 2 diabetes mellitus (T2DM) in women of childbearing age, prescribing antidiabetic medications in first-trimester pregnancy is becoming more common. Metformin treatment during this time is usually avoided in countries with well-resourced healthcare. This is based on historical concerns about safety to the foetus and the widespread availability of insulin.
View Article and Find Full Text PDFBackground: The use of proton pump inhibitors (PPIs) in older adults is high, often inappropriate, and may cause harm. Deprescribing is defined as the reduction, withdrawal, or discontinuation of inappropriate medication.
Objective: We conducted a systematic review to determine the effectiveness of interventions to deprescribe inappropriate PPIs in older adults.
Context: Patients with Addison's disease (AD) report impaired subjective health status (SHS). Since cortisol exhibits a robust circadian cycle that entrains other biological clocks, impaired SHS may be due to the noncircadian cortisol profile achieved with conventional glucocorticoid replacement. Continuous subcutaneous hydrocortisone infusion (CSHI) reproduces a circadian cortisol profile, but its effects on SHS have not been objectively evaluated.
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