[Dissociation of the anti-amnesic and antihypoxic effects of nootropic and antihypoxic preparations].

In experimental studies on mice it was shown that piracetam, Cleregil, centrophenoxine, pyritinol possessed the most pronounced anti-amnestic activity. A close effect was noted with Euclidan, 3-hydroxypyridine and ionol. GABAergic agents (sodium oxybutyrate, phenibut, pantogam), gutimine, nicotinoyl-GABA eliminated amnesia to a lesser extent.

[Characteristics of the antihypoxic properties of 3-hydroxypyridine-class antioxidants].

It was found during experiments using three models of hypoxia (hypobaric, normobaric, hemic) in mice that derivatives of 3-hydroxypyridine possess an antihypoxic effect. They are as active as sodium hydroxybutyrate but less active than gutimine. A clear-cut dependence of the antihypoxic activity on the radical character in the 2nd position of 3 hydroxypyridine was revealed.

[Relationship between the chemical structure and anticonvulsant activity of 3-hydroxypyridine derivatives].

It was revealed in experiments on mice, that 3-hydroxypyridine derivatives possess marked anticonvulsive activity, especially in convulsions induced by GABA-ergic substances, less in corasol, maximal electroshock and strychnine induced ones. The anticonvulsive activity in the rows of 2-substituted and 2.6-disubstituted derivatives of 3-hydroxypyridine gets increased due to the introduction of larger in volume alkyl substitutes into the 2nd molecule position.

[The role of GABA-benzodiazepine receptor complex in affecting the anxiolytic effect of 3-hydroxypyridines--new non-benzodiazepine tranquilizers].

The experiments on rats, using conflict situation method, have established that anxiolytic effect of 3-hydroxypyridine derivative is removed by bicucullin and picrotoxin, but not by Ro 5-3663, specific antagonist of benzodiazepine receptors Ro 15-1788 and inversive antagonist ethyl beta-carboline-3-carboxylate. The data obtained suggest that GABA-chloriontophor complex is involved into the realization of 3-hydroxypyridine anxiolytic effect.

[Effects of piracetam during prolonged use in an experiment].

The spectrum of the pharmacological activity of piracetam administered for a long time was studied in experiments on mice and rats. It was established that administration of piracetam (300-400 mg/kg i. p.

[Effect of 3-hydroxypyridine derivatives on the central nervous system].

Experiments on mice and rats were made to study the effect of inhibitors-antioxidants (3-hydroxypyridine derivatives) on the central nervous system. It was established that 3-hydroxypyridine derivatives (50 to 200 mg/kg) possess a broad spectrum of psychotropic effects. They cause normalization of behavior in conflict situations, exert an antiaggressive and anticonvulsant action (antagonism with corazol), are capable of potentiating the hypnotic effect of barbiturates, and of suppressing the animals' motor activity if given in high doses.