The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells.

Background: The E2F/RB pathway is frequently disrupted in multiple human cancers. E2F3 levels are elevated in prostate tumors and E2F3 overexpression independently predicts clinical outcome. The goals of this study were to identify direct transcriptional targets of E2F3 in prostate tumor derived cells.