Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.

Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to achieve accelerated responsiveness is unclear. We found that Delta-like1 (Dll1) Notch ligands in splenic fibroblasts regulated MZB cell pool size, migration, and function.

Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.

Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease relapse, making the development of new therapeutic strategies to target LSCs urgently needed. The use of mass spectrometry-based metabolomics profiling has enabled the discovery of unique and targetable metabolic properties in LSCs.

[Vitamin content of apple juices and ciders made from them].

The composition of apples is diverse and is represented by various compounds including vitamins. When processing apple fruits into ciders, vitamins take part in numerous biochemical processes and undergo significant changes. of this research was to study the content of vitamins in apple juice and ciders produced from fruits of 30 varieties and forms of apple tree of domestic and foreign selection.

Image dataset of benthic foraminifera in multicorer and gravity corer sediments from north-western Scotland shelf (North Atlantic Ocean).

Geological studies in the seas and oceans often give preference to the study of benthic foraminifera, which are a widespread and taxonomically diverse group of shell protozoa. In this paper, we present an extensive image dataset produced during the detailed micropaleontological analysis of 146 samples of bottom sediments collected by multicorer and gravity corer AMK-5656 from the Westray Basin on the north-western Scotland shelf (North Atlantic Ocean). In total, 106 taxa (at species and genera level) of benthic foraminifera were identified and photographed using the high-resolution microscope camera.

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive census of the bone marrow immune microenvironment in adult and pediatric patients with AML. We characterize unique inflammation signatures in a subset of AML patients, associated with inferior outcomes.

Treatment response in acute myeloid leukaemia-Clues in the biopsy core.

In their paper the authors describe distinct transcriptomic changes associated to treatment response in core bone marrow biopsies from patients with acute myeloid leukaemia. This finding raises the possibility that stratifying patients for treatment according to their transcriptomic profiles could improve patients' response and prognosis. Commentary on: Treaba et al.

Antimicrobial Activities of Secondary Metabolites from Model Mosses.

Plants synthetize a large spectrum of secondary metabolites with substantial structural and functional diversity, making them a rich reservoir of new biologically active compounds. Among different plant lineages, the evolutionarily ancient branch of non-vascular plants (Bryophytes) is of particular interest as these organisms produce many unique biologically active compounds with highly promising antibacterial properties. Here, we characterized antibacterial activity of metabolites produced by different ecotypes (strains) of the model mosses Physcomitrium patens and Sphagnum fallax.

Interleukin-17 governs hypoxic adaptation of injured epithelium.

Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is insufficient to trigger HIF1α in damaged epithelium. Instead, multimodal single-cell and spatial transcriptomics analyses and functional studies reveal that retinoic acid-related orphan receptor γt (RORγt) γδ T cell-derived interleukin-17A (IL-17A) is necessary and sufficient to activate HIF1α.

Image dataset of benthic foraminifera taxa from Denmark Strait sediments on the northwestern Iceland slope (North Atlantic Ocean).

The article presents an image dataset of benthic foraminifera assemblage in long sediment core AMK-5890 obtained during the 71st cruise of the research vessel Akademic Mstislav Keldysh in summer 2018 from the northwestern Iceland slope in Denmark Strait (North Atlantic Ocean). In the area of study, dense cold water masses of the East Greenland Current from the Nordic Seas contact and mix with warm salty water of the Irminger Current from the North Atlantic Ocean creating specific conditions for the benthic microfauna habitat which reflect forming the lower link of the global thermohaline circulation. The benthic foraminifera assemblages are a reliable indicator for paleooceanographic and ecological reconstructions describing the environments on the bottom in present and past.

Rational drug combinations with CDK4/6 inhibitors in acute lymphoblastic leukemia.

Despite improvements in outcomes for children with B- and T-cell acute lymphoblastic leukemia (B-ALL and T-ALL), patients with resistant or relapsed disease fare poorly. Previous studies have demonstrated the essential role of cyclin D3 in T-ALL disease initiation and progression and that targeting of the CDK4/6-cyclin D complex can suppress T-ALL proliferation, leading to efficient cell death in animal models. Studies in leukemia and other malignancies, suggest that schedule is important when combining CDK4/6 inhibitors (CDKi) with cytotoxic agents.

The Prevalence of Use of Various Post-Exercise Recovery Methods after Training among Elite Endurance Athletes.

There is now compelling evidence of the effectiveness of a range of post-exercise recovery techniques, including extended nights of sleep, cold water immersion, massage, and compression garments. Currently, limited information is available on post-exercise recovery methods used by elite endurance athletes. Therefore, this study investigated the actual methods of recovery used in this group of athletes.

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity.

Single-cell sequencing approaches have transformed our understanding of stem cell systems, including hematopoiesis and its niche within the bone marrow. Recent reports examined the bone marrow microenvironment at single-cell resolution at steady state, following chemotherapy treatment, leukemic onset, and aging. These rapid advancements significantly informed our understanding of bone marrow niche heterogeneity.

Cell-by-Cell Deconstruction of Stem Cell Niches.

Single-cell sequencing approaches offer exploration of tissue architecture at unprecedented resolution. These tools are especially powerful when deconvoluting highly specialized microenvironments, such as stem cell (SC) niches. Here, we review single-cell studies that map the cellular and transcriptional makeup of stem and progenitor niches and discuss how these high-resolution analyses fundamentally advance our understanding of how niche factors shape SC biology and activity.

[High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin].

Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat. The development of new targeted drugs (Hylteritinib, Venetoclax) significantly improved the survival of patients, but resistance, as well as cytotoxic anti-leukemia drugs, often occurs. The search for new molecular targets for the development of effective approaches for the treatment of AML is very urgent.

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.

A subset of B cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb to therapy-resistant disease. The bone marrow microenvironment may support B-ALL progression and treatment evasion. Utilizing single-cell approaches, we demonstrate B-ALL bone marrow immune microenvironment remodeling upon disease initiation and subsequent re-emergence during conventional chemotherapy.

Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.

During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide-MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficient mice, the thymus generates mature T cells expressing MHC-independent TCRs that recognize native conformational epitopes rather than linear antigenic-peptides presented by MHC. To date, no structural information of MHC-independent TCRs is available, and their structural recognition of non-MHC ligand remains unknown.

Image dataset of common benthic foraminiferal taxa in the North Atlantic seafloor surface sediments (59.5°N transect) between the Labrador sea and Faeroe-Shetland sill.

The article presents a microphotograph dataset of 106 taxa of benthic foraminifera (BF) from surface sediments collected at 26 grab station during RV 51st cruise (summer 2016). The selected stations are located along a 59.5°N transect in the North Atlantic.